Head of the Group

Prof. Dr. Nicolas Werbeck

Biomedicine and Biochemistry

Phone: +49 (0) 7720 307 4559
Email: werb@hs-furtwangen.de
Office C2.09

Selected Publications

Werbeck ND, Shukla VK, Kunze MBA, Yalinca H, Pritchard RB, Siemons L, et al. A distal regulatory region of a class I human histone deacetylase. Nat Commun. 11, 3841 (2020). doi:10.1038/s41467-020-17610-w.

Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A. 116, 2551–60 (2019). doi:10.1073/pnas.1812963116.

Zeymer C, Werbeck ND, Zimmermann S, Reinstein J, Hansen DF. Characterizing Active Site Conformational Heterogeneity along the Trajectory of an Enzymatic Phosphoryl Transfer Reaction. Angew Chem Int Ed Engl. 55, 11533–7. (2016). doi:10.1002/anie.201606238.

Werbeck ND, Kirkpatrick J, Reinstein J, Hansen DF. Using ¹⁵N-ammonium to characterise and map potassium binding sites in proteins by NMR spectroscopy. Chembiochem. 15, 543–8 (2014). doi:10.1002/cbic.201300700.

Werbeck ND, Kirkpatrick J, Hansen DF. Probing arginine side-chains and their dynamics with carbon-detected NMR spectroscopy: application to the 42 kDa human histone deacetylase 8 at high pH. Angew Chem Int Ed Engl. 52, 3145–7 (2013). doi:10.1002/anie.201209385.

Werbeck ND, Schlee S, Reinstein J. Coupling and dynamics of subunits in the hexameric AAA+ chaperone ClpB. J Mol Biol. 378, 178–90 (2008). doi:10.1016/j.jmb.2008.02.026.

Werbeck ND, Itzhaki LS. Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein. Proc Natl Acad Sci U S A. 104, 7863–8 (2007). doi:10.1073/pnas.0610315104.