Functional lateral flow arrays for the identification of multi-resistant pathogens
Scientists at the IPM within the “TechPat nano” project are involved in technological system development to prepare the next generation of near-patient diagnostics. A therapy-accompanying, non-invasive monitoring test after kidney transplantation is being developed. This test is designed to enable early detection of transplant rejection and functions by determining the molecular marker “kynurenine”, a degradation product of the amino acid tryptophan. In this way, the test enables immunosuppressants to be adjusted in a course-specific manner and thus offers the patient a high level of added value and safety.
The single molecule analysis of kynurenine will be performed using nanopore biosensors – for which the synthesis and characterization of corresponding kynurenine-competitor conjugates is being carried out at the Institute of Precision Medicine. Enzyme-based approaches for the detection of kynurenine are also being developed. Furthermore, an LC-MS based reference method for the quantification of kynurenine in real samples is developed and applied to corresponding real samples. The scientists also undertake the synthesis of functional acrylate-based monomers for the production of polymer membranes.
Hahn-Schickard Institute for Microanalytic Systems
University Hospital Tübingen (General Surgery)
University Hospital Freiburg (Institute for Medical Microbiology and Hygiene)
Kompetenznetzwerk für Digitale Medizin
University Freiburg (Physiological Institute)
Hahn-Schickard Institute for Micro and Information Systems
Hahn-Schickard Institute for Microstructure Technology
Medical Natural Science Institute Reutlingen
Institut für Lasertechnologien in der Medizin und Meßtechnik Ulm
The project is funded within the funding line “Forum Gesundheitsstandort BW” by BIOPRO Baden-Württemberg GmbH and by the Ministry of Economics, Labor and Housing (WM BWL), FKZ 35-4223.10/10