Group Members

Dr. Lukas Wichmann

Academic Staff – Post Doc

lukas.wichmann@hs-furtwangen.de

Project:

FlowArray

Filip Paskali, M.Sc.

Academic Staff

w.schary@hs-furtwangen.de

Project:

FlowArray

InfektResonator

AsphyxDx

CompanionDx

 

Jonathan Simantzik, M.Sc.

Academic Staff

j.simantzik@hs-furtwangen.de

Project:

FlowArray

InfektResonator

AsphyxDx

CompanionDx

Current Projects

FlowArray – Functional lateral flow arrays for the identification of multi-resistant pathogens

The aim of project “FlowArray” is to develop functional multiplex lateral flow microarrays (LFMAs) for point-of-care (POC) analysis of infections with multi-resistant pathogens. The microarray format allows identification of a variety of different pathogens, their resistances, and effective inhibitors on a single test strip.

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AsphyxDx – Translation of clinical markers of neonatal oxygen deficiency into a new diagnostic tool to prevent early infant brain damage and guide individualized therapy

The aim of project “AsphyxDx” is to develop a diagnostic approach for perinatal asphyxia based on the quantification of small endogenous metabolites using nanopore-based, as well as other, rapid tests. Reliable diagnosis of perinatal asphyxia is the prerequisite for timely therapy based on cold treatment (hypothermia) to avoid irreversible late damage.

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CompanionDx Hypothermie – Joint project: Therapy-accompanying diagnosis for oxygen deficiency in newborns

The aim of project “CompanionDx” is to identify metabolic biomarkers for the differentiation between responders and non-responders of hypothermia therapy applied during the treatment of children with perinatal asphyxia. The biomarkers will be used for early prediction if an affected child will benefit from hypothermia therapy or if an alternative therapeutic strategy should be chosen.

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InfektResonator_WGM – Microresonators for point-of-care diagnostics of pathogens

The aim of the InfektResonator project is to further develop Whispering Gallery Mode (WGM) sensor technology into a rapid analysis platform for rapid diagnostic tests. The low detection limits of up to 50 fmol are to be used for the analysis of antibiotic resistance of pathogens without prior culture.

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Selected Publications

Ruppert, C., Kaiser, L., Jacob, L.J. et al. Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assay. J Nanobiotechnol 18, 130 (2020). https://doi.org/10.1186/s12951-020-00688-1

Ruppert C, Phogat N, Laufer S, Kohl M, Deigner HP. A smartphone readout system for gold nanoparticle-based lateral flow assays: application to monitoring of digoxigenin. Mikrochim Acta. 2019 Jan 19;186(2):119. https://doi.org/10.1007/s00604-018-3195-6

Selected Software Publications

Former Members

Former Projects

In-Vitro Translation Organtoxic metabolic biomarker of liver failure

In-Vitro Translation Organtoxic metabolic biomarker of liver failure from clinical and experimental specimens
funded by BfR

Robust Risk Estimation

Robust Risk Estimation
funded by the Volkswagen Foundation